Custom Bioconjugation Service

We help our customers with "off the shelf" conjugation products using our advanced conjugation processes. We have all of the resources and expertise needed to fulfill such tasks, from small molecule synthesis to big molecule modification and conjugation, purification, analysis, and testing. We take care of the entire work flow, from molecular design to manufacturing. Our expertise covers a wide range of small molecules and biopolymers. In a typical custom conjugation service, customers specify what kinds of molecules (either commercial or their own molecules) are to be conjugated. CellMosaic will design the molecule using commercial linkers, and then use our process to make the conjugate and supply it to the customer.

Features and Benefits of our services:

  • Wide range: We offer a complete solution for biologists by sourcing (internally or externally) all raw materials and assembling the final product.
  • Flexibility in conjugation chemistry: CellMosaic strategically designs its conjugation chemistry around the targeted biopolymer's properties and the customer's intended use. CellMosaic generates the bioconjugate that best meets the customer's downstream research requirements.
  • Quality: CellMosaic provides high quality services. We provide all of the necessary analytical data to facilitate the customer’s understanding of the product.
  • AP—Oligo Conjugate Example 1: Preparation of single labeled AP-oligo conjugates.

    AP—Oligo Conjugate

    Alkaline phosphatase (AP) is a hydrolase enzyme responsible for removing phosphate groups from many types of molecules, such as nucleotides and proteins. It is used to detect target proteins through chromogenic, chemiluminescent, or fluorescent outputs...

  • Fab—HRP conjugate Scheme: thiol modified Fab reaction with maleimide activated enzyme

    Fab—HRP conjugate

    CellMosaic routinely performs HRP conjugation with antibody fragments and has Personalized Conjugation Kits (PerKit™), please click here to learn our PerKit™ product line. For large scale or project beyond the scope of PerKit™...

  • Oligonucleotide Labeling Scheme: oligo labeling through an NHS ester

    Oligonucleotide Labeling

    Oligo nucleotides (DNA or RNA) can be labeled anywhere (3', 5', or via a modified base). The conjugation can be performed in either solid phase or post-synthesis solution phase. Usually a single pure labeled oligo can be obtained. The advantages of...

  • Oligo—Antibody Conjugate Scheme: thiol modified IgG reaction with maleimide activated oligo

    Oligo—Antibody Conjugate

    CellMosaic routinely performs oligo-antibody conjugation for customers and has Personalized Conjugation Kit (PerKit™) for oligo-antibody with average 1-3 oligos per antibody (Cat#: CM53405). For large scale, single labeling, or project beyond the...

  • Peptide Labeling Example 1: Biotinylation of a peptide (>99.9% purity by HPLC for a single labeled product)

    Peptide Labeling

    Peptides can be labeled using a variety of methods depending on their amino acid composition. The N-terminal amine can be labeled if no internal Lys residues are present in the peptide. The C-terminal acid can be labeled if no Glu and Asp residues are...

  • Peptide—Oligo Conjugate Example 1: Synthesis and purification of BHQ2 oligo-peptide conjugates.

    Peptide—Oligo Conjugate

    At CellMosaic, we routinely synthesize oligo-peptide conjugates for customers, in particularly, the ones that customers have difficulties in obtaining themselves due to the properties of the starting oligos or peptides. We use various strategies to...