Prepare Your Own Custom Drug-Conjugates for Screening and Proof-of-Concept with CellMosaic’s Personalized Kits (PerKit®)

Since 2017, CellMosaic has been providing PerKits® to help our life science clients quickly evaluate their biologics of interest (antibodies, proteins, peptides, and oligonucleotides) through direct conjugation with a range of key payloads (such as chemotherapeutic drugs and toxins) using traditional linker chemistry. Kits are available in various configurations, offering a variety of conjugation strategies. Some drug conjugation kits apply to general payloads with certain functional groups, such as carboxylic acids or amines. Others provide the selected, standard linkage molecules conjugated to a specific payload, complete with appropriate reactive modifications to directly attach the payload and linker to the biologic of interest. The kits include all reagents and procedures necessary for attaching the selected payload directly to the customer's biologics and pfor urifying the final drug conjugates. All the customer needs to supply is their biologics and standard lab equipment.

Perkit™ Drug Conjugation Selection Guide

Product#	Protein	Drug	Scale of Reaction (Standard Kit)	Labeling Chemistry	Linkage
CM11429	IgG Ab	No drug (VC-PAB linker only)	1-3 mg	Reduced thiol	Releasable
CM51403	IgG Ab	Acid	1-3 mg	Surface amine	Stable
CM11410 (x1, x3)	IgG Ab	DM1	1-3 mg	Surface amine	Stable
CM11406 (x1, x3)	IgG Ab	Doxorubicin	1-3 mg	Surface amine	Stable
CM11407 (x1, x3)	IgG Ab	Methotrexate	1-3 mg	Surface amine	Stable
CM11409 (x1, x3)	IgG Ab	MMAE	0.1 mg, 1-3 mg	Reduced thiol	Releasable
CM11422 (x1, x3)	IgG Ab	MMAF	1-3 mg	Reduced thiol	Stable
CM11425 (x1, x3)	IgG Ab	MMAF	1-3 mg	Reduced thiol	Releasable
CM11408 (x1, x3)	IgG Ab	SN38	1-3 mg	Surface amine	Releasable
CM11431 (x1, x3)	IgG Ab	Deruxtecan	1-3 mg	Reduced thiol	Releasable
CM52408	Any protein	Acid	15-50 nmol	Surface amine	Stable
CM11414 (x1, x3)	Any protein	DM1	6.67-20 nmol	Surface amine	Stable
CM11430 (x1, x3)	Any protein	SN38	6.67-20 nmol	Surface amine	Releasable
CM11413 (x1, x3)	Any protein	MMAE	6.67-20 nmol	Surface amine	Releasable
CM11416 (x1, x3)	F(ab')2	MMAE	0.73-2.2 mg	Surface amine	Stable
CM11419 (x1, x3)	F(ab')2	DM1	0.73-2.2 mg	Reduced thiol	Releasable

(Note: Additional kit configurations can be added based on customer request. If you do not see your desired configuration listed, please inquire or request a custom bioconjugation service.)

Bioconjugate Drug Development & Manufacturing

CellMosaic is a premier service provider, offering our expertise in all drug conjugation-related services, particularly for projects involving more complex chemistry, larger product volumes, or tighter specifications for the final product. CellMosaic’s services cover all standard, non-proprietary conjugations. For more information, please click here.

AqueaTether^® Technology

When a drug conjugate cannot be synthesized using classical linkers, or the effectiveness of the drug conjugate is compromised by the number of toxins loaded onto the antibody, CellMosaic has developed novel super-hydrophilic and high-loading AqueaTether^® (AqT^®) linkers to address these challenges. For more information about AqT^® technologies, please click here. To learn how to access this technology for your novel ADC development, please click here.