Biopurification Services

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CellMosaic offers purification solutions spanning small molecules to complex biopolymers, with a focus on the isolation of discrete, structurally defined bioconjugates. Our approach emphasizes method development based on the physicochemical and structural properties of each conjugate to achieve high purity and batch consistency.

Peptide and oligonucleotide conjugates are typically purified via reversed-phase HPLC, leveraging hydrophobic interactions for high-resolution separation. Antibody-based conjugates are commonly purified using affinity chromatography (e.g., Protein A/G), ensuring specificity and preservation of biological activity. Other macromolecular conjugates, such as HRP-based systems, are often purified using size-exclusion chromatography to separate species based on hydrodynamic radius.

Custom purification strategies can be developed for complex or non-standard conjugates. Please request a quote to discuss your specific project.

Standard Services

Code	Service Type	Description
PS0001	Standard HPLC	Standard HPLC purification uses a C18 column for the purification of peptides (small proteins) and oligos. Purity >90%.
PS0002	Gel Filtration	Purification of conjugates based on molecular weight (size-exclusion chromatography).
PS0003	Protein A Chromatography	Purification of IgG molecules.
PS0004	Antigen Affinity Chromatography	For specific antibody purification. Please supply immobilized antigen media or request a custom immobilization.
PS0005	Avidin/Streptavidin Purification	Uses an immobilized iminobiotin column.
PS0006	Metal Ion Affinity Chromatography	For purification of proteins containing a His tag or purification of antibody-enzyme conjugates.

HPLC: high performance liquid chromatography.

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