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AqT® Immobilization

CellMosaic is developing next-generation immobilization kits and products using sugar alcohol-based AqT® linkers. In many cases, we need to load very hydrophobic small molecules (antigen molecules) onto a solid support. Many of these immobilizations must be done in an aqueous environment. Even with sugar-based agarose beads, we experience challenges obtaining high loading with conventional ethylene or PEG-based linkers. When we manage to achieve high loading, beads end up aggregating/clustering together and are difficult to use. On the other hand, there have been many developments in non-sugar-based beads for immobilization purposes, such as poly(methyl methacrylate) (PMMA). The surface of PMMA is very hydrophobic. AqT® modification can convert the surface of these beads to be hydrophilic and more biocompatible. CellMosaic is currently developing AqT®-modified beads and immobilization kits/products. If you are interested in co-developing AqT® beads and immobilization kits, please let us know.

Coming soon!