Welcome to CM Online Store!
Antibody Drug Conjugate Kits!
AqT bioconjugates coming soon!
Shop by Brand
Custom Services
Antibodies, similar to other proteins, have functional groups from natural amino acids that can be used for labeling and conjugation (for example, the surface amine from Lys or N-terminal amine; the surface carboxylic acid group from Asp, Glu, or C-terminal acid; and the phenolic group from Tyr). Antibodies also have unique disulfide bonds at the hinge region of their strucure that can be selectively cleaved and targeted for labeling. Traditional antibody labeling technologies usually take advantage of multiple Lys groups located in the antibody, however modification of the Lys groups changes the overall pI of the antibody and may lead to higher nonspecific binding and If some of the modified or conjugated Lys residues are located at the antigen binding sites, this method may produce partially active or inactive antibody conjugates that may not bind to the antigen.
At CellMosaic, we spend considerable time developing processes for labeling an antibody at a single or few predictable sites while retaining antigen binding affinity and specificity. We have used these processes to develop our Personalized Conjugation Kits (PerKit™) for antibody fragmentation, antibody labeling, and conjugation.
For large-scale projects beyond the scope of PerKit™ configurations or our routine conjugation services, please contact us for a quote.
We also provide hapten–carrier bioconjugation services for antibody production. Typical haptens include proteins, peptides, oligonucleotides, and small molecules. Typical carrier proteins are keyhole limpet hemocyanin (KLH), bovine serum albumin (BSA), and ovalbumin. At the customer's request, CellMosaic can also use synthetically designed organic molecules or natural polymers as carriers.
Selected examples: