Product Description
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| Product Sheet | |
| SDS | COA_Lot#0630E |
CellMosaic’s S-Methyl DM1 Control Set is a ready-to-use solution for in vitro research, formulated to simplify your workflow and minimize handling risks of this potent cytotoxic agent. S-methyl DM1 is the primary cellular or liver metabolite of ADC or other conjugates prepared with DM1. DM1 (mertansine) is a thiol-containing derivative of maytansine. It binds to tubulin and inhibits the assembly of microtubules. DM1 is used to prepare antibody-drug conjugates, such as trastuzumab emtansine (abbreviated as T-DM1). DM1 is not very stable in aqueous solution and can be oxidized or dimerized. CellMosaic’s S-methyl DM1 is a high purity product that can serve as a control.
This control set contains 6 tubes of a 10 µM S-methyl DM1 solution in DMSO, a concentration suitable for most biological research and cell-based assays.
The 10 µM concentration is intentionally set within a safe, research-appropriate range for analytical studies, both quantitative and qualitative. Each tube is intended for a single experiment, enabling straightforward dilution (see Table 1 for suggested dilutions). The S-Methyl DM1 solution is pre-formulated and stable at room temperature, requiring no preparation before use or dilution.
Drug Information
- Chemical name: S-Methyl DM1 (S-Methyl Mertansine)
- Chemical formula:C36H50ClN3O10S
- Molecular weight: 752.32 Da CAS number:912569-84-7
- Mechanism of Action: Inhibits cell division by blocking the polymerization of tublin
- Activities: Anti-mitotic, Anti-tumor
Key Features of the Product
- Pre-formulated 10 µM stock in DMSO —no preparation needed.
- Convenient format: 6 single-use tubes for consistent results.
- Ideal for:
- Drug screening
- Cell-viability, proliferation and cytotoxicity assays
- Other qualitative and quantitative studies
- Sufficient volume for replicates.
