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ADC and ODC Analysis
A fully characterized ADC is a key to understanding the therapeutic effect of an ADC.
CellMosaic uses a variety of ways to analyze ADC. The following table provides suggestions for DAR analysis using CellMosaic's ADC kit. CellMosaic also provides ancillary bioanalytical and purification services, and assay reagents/kits for our customers to use our ADC kits.
ADC Summary with DAR Analysis Suggestions (download pdf file)
Name of ADC KitPart Number |
Protein |
Drug |
Linker |
Labeling Chemistry (Linkage) |
Recommended Analysis for DAR Determination⸙ |
|||
|---|---|---|---|---|---|---|---|---|
SEC |
HIC |
UV Abs Ratio |
●MALDI ●ESI-MS |
|||||
|
ADC Control Kit with VC-PAB Linker |
IgG Ab | None | Alkyl-VC-PAB |
Reduced thiol (Releasable Linker) |
 |
|
|
|
|
Antibody Mertansine (DM1) Conjugation Kit |
IgG Ab | DM1 | SMCC |
Surface amine (Stable Linker) |
|
 |
|
|
|
Antibody Doxorubicin Conjugation Kit |
IgG Ab | Doxorubicin | Alkyl |
Surface amine (Stable Linker) |
|
|
|
|
|
Antibody Methotrexate Conjugation Kit |
IgG Ab | Methotrexate | Alkyl |
Surface amine (Stable Linker) |
|
|
|
|
|
Antibody MMAE Conjugation Kit (With VC-PAB Linkage) |
IgG Ab | MMAE | Alkyl-VC-PAB |
Reduced thiol (Releasable Linker) |
|
|
|
|
|
Antibody Mc-MMAF Conjugation Kit |
IgG Ab | MMAF | Alkyl |
Reduced thiol (Stable Linker) |
|
|
|
|
|
Antibody MMAF Conjugation Kit (With VC-PAB Linker) |
IgG Ab | MMAF | Alkyl-VC-PAB |
Reduced thiol (Releasable Linker) |
|
|
|
|
|
Antibody SN38 Conjugation Kit |
IgG Ab | SN38 | Alkyl |
Surface amine (Releasable Linker) |
 |
|
 |
|
|
F(ab')2 MMAE Conjugation Kit (With VC-PAB Linkage) |
F(ab')2 | MMAE | Alkyl-VC-PAB |
Reduced thiol (Releasable Linker) |
|
|
|
|
|
F(ab')2 Mertansine (DM1) Conjugation Kit |
F(ab')2 | DM1 | SMCC |
Surface amine (Stable Linker) |
|
|
|
|
| Recommended |
Result may vary or limited information |
Not recommended |
⸙Note: The above recommendations are only for DAR determination. However, it is advised to perform all of the above analysis to fully characterize the ADC.