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ADC and ODC Analysis
A fully characterized ADC is a key to understanding the therapeutic effect of an ADC. CellMosaic uses a variety of ways to analyze ADC. The following table provides suggestions for DAR analysis using CellMosaic's ADC kit. CellMosaic also provides ancillary bioanalytical and purification services, and assay reagents/kits for our customers to use our ADC kits.
ADC Summary with DAR Analysis Suggestions (download pdf file)
Name of ADC Kit Part Number |
Suggested Antibody |
Drug |
Linker |
Labeling Chemistry (Linkage property) |
Recommended Analysis for DAR Determination⸙ |
|||
|---|---|---|---|---|---|---|---|---|
SEC |
HIC |
UV Abs Ratio |
●MALDI●ESI-MS |
|||||
|
ADC Control Kit with VC-PAB Linker CM11429 |
IgG type | None | Alkyl-VC-PAB |
Reduced thiol (Releasable Linker) |
 |
|
|
|
|
Antibody Mertansine (DM1) Conjugation Kit CM11410 |
IgG type | Mertansine (DM1) | SMCC |
Surface Amine (Stable Linker) |
|
 |
|
|
|
Antibody Doxorubicin Conjugation Kit CM11406 |
IgG type | Doxorubicin | Alkyl |
Surface Amine (Stable Linker) |
|
|
|
|
|
Antibody Methotrexate Conjugation Kit CM11407 |
IgG type | Methotrexate | Alkyl |
Surface amine (Stable Linker) |
|
|
|
|
|
Antibody MMAE Conjugation Kit (With VC-PAB Linkage) CM11409 |
IgG type | MMAE | Alkyl-VC-PAB |
Reduced thiol (Releasable Linker) |
|
|
|
|
|
Antibody Mc-MMAF Conjugation Kit CM11422 |
IgG type | MMAF | Alkyl |
Reduced thiol (Stable Linker) |
|
|
|
|
|
Antibody MMAF Conjugation Kit (With VC-PAB Linker) CM11425 |
IgG type | MMAF | Alkyl-VC-PAB |
Reduced thiol (Releasable Linker) |
|
|
|
|
|
Antibody SN38 Conjugation Kit CM11408 |
IgG type | SN38 | Alkyl |
Surface amine (Releasable Linker) |
 |
|
 |
|
|
F(ab')2 MMAE Conjugation Kit (With VC-PAB Linkage) CM11416 |
F(ab')2 | MMAE | Alkyl-VC-PAB |
Reduced thiol (Releasable Linker) |
|
|
|
|
|
F(ab')2 Mertansine (DM1) Conjugation Kit CM11419 |
F(ab')2 | Mertansine (DM1) | SMCC |
Surface amine (Stable Linker) |
|
|
|
|
| Recommended |
Result may vary or limited information |
Not recommended |
⸙Note: The above recommendations are only for DAR determination. However, it is advised to perform all of the above analysis to fully characterize the ADC.