Prepare Your Own Custom Drug-Conjugates for Screening and Proof-of-Concept with CellMosaic’s Personalized Kits (PerKit®)

Since 2017, CellMosaic has provided PerKits® to help life science customers quickly evaluate their biologics of interest (such as antibodies, proteins, peptides, and oligonucleotides) through direct conjugation with a range of key payloads (e.g., chemotherapeutic drugs and toxins) using traditional linker chemistry. The kits are available in various configurations, offering multiple conjugation strategies. Some drug conjugation kits are compatible with general payloads containing specific functional groups, such as carboxylic acids or amines, while others provide selected, standard linkage molecules conjugated to a specific payload. These kits include appropriate reactive modifications to directly attach the payload and linker to the biologic of interest. Each kit includes all necessary reagents and procedures for attaching the selected payload to the customer's biologics and for purifying the final drug conjugates. Customers need only supply their biologics and standard lab equipment.

As of August 2024, customers from over 112 organizations worldwide have used CellMosaic's ADC kits. For publications using CellMosaic's ADC kits, please check here.

Perkit® Drug Conjugation Selection Guide

Product#	Protein	Drug	Scale of Reaction (Standard Kit)	Labeling Chemistry	Linkage
CM11429	IgG Ab	No drug (VC-PAB linker only)	1-3 mg	Reduced thiol	Releasable
CM51403	IgG Ab	Acid	1-3 mg	Surface amine	Stable
CM11410 (x1, x3)	IgG Ab	DM1	1-3 mg	Surface amine	Stable
CM11406 (x1, x3)	IgG Ab	Doxorubicin	1-3 mg	Surface amine	Stable
CM11407 (x1, x3)	IgG Ab	Methotrexate	1-3 mg	Surface amine	Stable
CM11409 (x1, x3)	IgG Ab	MMAE	0.1 mg, 1-3 mg	Reduced thiol	Releasable
CM11422 (x1, x3)	IgG Ab	MMAF	1-3 mg	Reduced thiol	Stable
CM11425 (x1, x3)	IgG Ab	MMAF	1-3 mg	Reduced thiol	Releasable
CM11408 (x1, x3)	IgG Ab	SN38	1-3 mg	Surface amine	Releasable
CM11431 (x1, x3)	IgG Ab	Deruxtecan	1-3 mg	Reduced thiol	Releasable
CM52408	Any protein	Acid	15-50 nmol	Surface amine	Stable
CM11414 (x1, x3)	Any protein	DM1	6.67-20 nmol	Surface amine	Stable
CM11430 (x1, x3)	Any protein	SN38	6.67-20 nmol	Surface amine	Releasable
CM11413 (x1, x3)	Any protein	MMAE	6.67-20 nmol	Surface amine	Releasable
CM11416 (x1, x3)	F(ab')2	MMAE	0.73-2.2 mg	Surface amine	Stable
CM11419 (x1, x3)	F(ab')2	DM1	0.73-2.2 mg	Reduced thiol	Releasable

(Note: Additional kit configurations can be added upon customer request. Please inquire if your desired configuration is not listed, or request a custom bioconjugation service.)

Bioconjugate Drug Development & Manufacturing

CellMosaic is a premier service provider, offering expertise in all drug conjugation-related services, particularly for projects requiring complex chemistry, larger product volumes, or stringent specifications for the final product. CellMosaic’s services encompass all standard, non-proprietary conjugations. For more information, please click here.

AqueaTether® Technology

When a drug conjugate cannot be synthesized using classical linkers, or when the effectiveness of the drug conjugate is compromised by the number of toxins loaded onto the antibody, CellMosaic has developed novel, super-hydrophilic, high-loading AqueaTether^® (AqT®) linkers to address these challenges. For more information about AqT® technologies, please click here. To learn how to access this technology for your novel ADC development, please click here.