Product Description
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| Product Sheet | |
| SDS | COA_Lot#0531D |
Deruxtecan is an exatecan-derivative topoisomerase I inhibitor. Deruxtecan is a thiol reactive derivative of DXd that contains enzymatically cleavable peptide linker GGFG. Trastuzumab Deruxtecan, sold under the brand name Enhertu was approved by US FDA for treating metastatic HER2-postive breast cancer. This product is a control ADC for any IgG type antibody labeled with Deruxtecan, particularly any ADC made using CellMosaic's Antibody Deruxtecan Conjugation Kit (Cat#: CM11431). The product uses a human IgG1 subtype antibody that does not bind to the target. It has an average of 3-5 Deruxtecan loaded on each antibody and can be used for assessing the effect of Deruxtecan alone (non-specific toxicity). The product uses a very low endotoxin level antibody as a starting material (≤0.5 EU/mg by the LAL method). The preparation and purification are conducted under a pyrogen free environment.
The final conjugate is lyophilized from pH 6.5 citrate buffer containing sugar-based stabilizer for easy shipping and storage.
The product is sold as 1 vial of 100 microgram (Cat# CM51103-100UG), 1 vial of 500 micrograms (Cat# CM51103-500UG), or 2 vials of 500 micrograms (Cat# CM51103-1MG). For bulk orders, please contact us for a quote.
Chemical Information
- Chemical name: ADC Control hIgG1-Deruxtecan
- Chemical formula: N/A
- Molecular weight: 152KDa CAS number: N/A
Specification
- Physical Appearance: Colorless to white lyophilized powder in a microcentrifuge tube
- Storage Temp.: -20°C
- Purity: ≥99% of Deruxtecan labeled antibody by SEC HPLC, free of any unreacted Deruxtecan
- Endotoxin Level: ≤0.5 EU/mg by the LAL method
- Drug Over Antibody Ratio (DAR): 3 to 5 by UV ratio, HIC HPLC, and difference MALDI-TOF MS
Antibody Information
- Immunogen: HEL (Hen Egg Lysozyme)
- Species Reactivity: chicken
- Expression Host: CHO-S cell line
- Class: Human IgG1, Kappa
- Antibody Type: Monoclonal
- Applications: ELISA, FACS, IF, IHC, in vivo studies, IP, WB
- Purification Method: Affinity purified
Related Products
Antibody Deruxtecan Conjugation Kit (Product #: CM11431): ADC kit designed for labeling any IgG type antibody with Deruxtecan using a cleavable GGFG linker for early stage screening of customer's antibody.
