Product Description
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| Product Sheet | |
| SDS | COA_Lot#082919 |
DM1 (mertansine) is a thiol-containing derivative of maytansine. It binds to tubulin and inhibits the assembly of microtubules. DM1 is used to prepare ADCs (antibody-drug conjugates), such as trastuzumab emtansine (abbreviated as T-DM1). This BSA-DM1 conjugate is designed with similar linker chemistry as T-DM1 and is synthesized at CellMosaic® for our customers' usage in immunization or immunoassay. Maleimide functional groups are first introduced to the BSA followed by a reaction of the maleimide group with the thiol of DM1 to form the BSA-DM1 conjugate.
The final conjugate is lyophilized from phosphate buffered saline containing sugar-based stabilizer for easy shipping and storage.
The product is sold as either 1 vial of 1 mg (Cat# CM52110-1MG) or 5 vials of 1 mg (Cat# CM52110-5MG). For bulk orders, please contact us for a quote.
Chemical Information
- Chemical name: BSA-DM1 (Mertansine) Conjugate
- Chemical formula: N/A
- Molecular weight: 70KDa; CAS number: N/A
Specification
- Physical appearance: white to off-white preservative-free lyophilized powder in a 2.0 mL centrifuge tube
- Storage temp.: -20 °C
- Purity: ≥ 99 % of conjugates by HPLC
- Amount of DM1 loaded per BSA molecule: ~4
