Product Description
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| Product Sheet | |
| SDS | COA (Lot S301.2.S5F49) |
Alprenolol is an antagonist for ß1 and ß2 adrenergic receptors. This biotin-alprenolol conjugate is first designed and synthesized at CellMosaic® for our customers' usage of detecting ß-AR. Alprenolol is derivatized with a cysteamine linkage first at a position that is known to not interfere with the receptor binding, then reacts with biotin NHS ester to form the conjugate.
Chemical Information
- Chemical name: Biotin-Alprenolol Conjugate
- Chemical formula: C27H44N4O6S2
- Molecular weight: 584.79; CAS number: N/A
Specification
- Physical appearance: lyophilized powder or oil-like film
- Storage temp.: -20 °C
- Purity: ≥ 95 % by HPLC
Selected Citations from Customers Who Use Our Product
Rose, J. A.; Wanner, N.; Cheong, H. I.; Queisser, K.; Barrett, P.; Park, M.; Hite, C.; Naga Prasad, S. V.; Erzurum, S.; Asosingh, K. Flow Cytometric Quantification of Peripheral Blood Cell β-Adrenergic Receptor Density and Urinary Endothelial Cell-Derived Microparticles in Pulmonary Arterial Hypertension PLoS One 2016, 11(6), e0156940, DOI: 10.1371/journal.pone.0156940
Christoffersson, G.; Ratliff, S. S.; von Herrath, M. G. Interference with pancreatic sympathetic signaling halts the onset of diabetes in mice Science Advances: Immunology, 2020, 6(35), eabb2878 DOI: 10.1126/sciadv.abb2878
Mohiuddin, I. S..; Wei, S.-J.; Yang, I.-H.; Martinez, G. M..; Yang, S.; Cho, E. J.; Dalby, K. N.; Kang, M. H. Development of cell-based high throughput luminescence assay for drug discovery in inhibiting OCT4/DNA-PKcs and OCT4–MK2 interactions Biotechnology and Bioengineering 2021, 118(5): 1987–2000 DOI: 10.1002/bit.27712
Kaminski, T.; Zhdanov, V. P.; Höök, F. Single-molecule Dynamic In-Solution Inhibition Assay: A Method for Full Kinetic Profiling of Drug Candidate Binding to GPCRs in Native Membranes bioRxiv September 16, 2021. DOI: 10.1101/2021.09.16.460640
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