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Bioconjugate Drug Development & Manufacturing

CellMosaic offers a complete drug discovery and development program for drug conjugates and drug modifications using classical linkers and polymers. Over the years, CellMosaic has delivered many high-quality conjugate drugs for customers based on our advanced conjugation processes. These processes can be modified for new conjugate drug development for our customers.

 The services we provide include:

• Custom design and development of conjugation strategies to fit your needs (customer owns the rights for the compound)
• Proof-of-concept Studies: CellMosaic has in-house conjugation processes ready to quickly synthesize any drug conjugates for initial proof-of-concept studies.
• Conjugate Drug Discovery:
• Evaluation of the labeling sites
• Evaluation of the linkage or labeling chemistry (stable vs. cleavable)
• Evaluation of the linkers or polymers
• Conjugate Drug Development:
• Stability studies
• Development of purification method for drug bioconjugates
• Development of bio-analytical methods (HIC, SEC, cation or anion exchange HPLC, MS)
• pK studies of conjugate drugs in blood and tissue extracts
• Lipid formulation studies
• Process development
• Process transfer

Examples of Classical Drug Conjugates and Drug Modifications frequently done at CellMosaic:

• Peptide–small molecule drug conjugate
• Oligo based drug conjugate such as oligo-peptide
• Antibody-protein or peptide conjugate
• Protein-small molecule drug conjugate
• Polymer-small molecule drug conjugates
• Other drug conjugates

Depending on the needs of a customer’s project, the typical turn-around time for synthesizing any drug conjugates for initial proof-of-concept is 6-8 weeks. Please contact us to discuss your project.

AqueaTether® (AqT®) Therapeutics, a separate division of CellMosaic, has developed novel super-hydrophilic and high-loading AqT® linkers and polymers for drug conjugation. To explore this opportunity and learn more about AqT® platform technologies, please visit our website at aqttherapeutics.com.